Monitoring and Modeling Horizontal Gene Transfer  

Oleh:

Nielsen, Kaare M. ; Townsend, Jeffrey P.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Nature Biotechnology: The Science and Business of Biotechnology vol. 22 no. 9 (Sep. 2004), page 1110-1114.
Topik: GENES; monitoring; modeling; horizontal gene transfer

Ketersediaan

Perpustakaan Pusat (Semanggi) Nomor Panggil: NN9.1 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

Monitoring effects have failed to identify horizontal gene transfer (HGT) events occuring from transgenic plants into bacterial communities in soil or intestinal environments. The lack of such observations is frequently cited in biosafety literature and by regulatory risk assessment. Our analysis of the sensitivity of current monitoring efforts shows that studies to date have examined potential HGT events occuring in less than 2 g of sample material, when combined. Moreover a population genetic model predicts that rare bacterial transformants acquiring transgenes require years of growth to out compete wild type bacteria. Time of sampling is therefore crucial to the useful implementation of monitoring. A population genetic approach is advocate for elucidating the necessary sample sizes and times of sampling for monitoring HGT into large bacterial populations. Major changes in current monitoring approaches are needed, including explicit consideration of the population size of exposed bacteria, the bacterial generation time, the strength of selection acting on the transgene carrying bacteria and the sample size necessary to verify or falsify the HGT hypotheses tested.

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