Keeping Dry and Crossing Membranes  

Oleh:

Fernandez, Ariel

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Nature Biotechnology: The Science and Business of Biotechnology vol. 22 no. 9 (Sep. 2004), page 1081-1084.
Topik: MEMBRANES; keeping dry; crossing membranes

Ketersediaan

Perpustakaan Pusat (Semanggi) Nomor Panggil: NN9.1 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

Water sustains life but also imposes constraints on what life should be like. Its high dipole moment, proton donor acceptor dual nature and rotational freedom make it a powerful former of hydrigen bonds. In soluble proteins, this property places stringent constraints on the way proteins interact and fold. I argue here that the manipulation of intramolecularly inderdehydrated or underwrapped electrostatic interactions in proteins can be exploited in engineering strategies to create molecules with an enhanced ability to traverse biological membranes, with potential implications for oral delivery of peptide based drugs.

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