Antidote - Mediated Control of an Anticoaguant Aptamer in Vivo  

Oleh:

Rusconi, Christopher P. ; Roberts, Joseph D. ; Pitoc, George A. ; Nimjee, Shahid M. ; White, Rebekah R. ; Quick, George ; Scardino, Elizabeth ; Fay, William P. ; Sullenger, Bruce A.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Nature Biotechnology: The Science and Business of Biotechnology vol. 22 no. 11 (Nov. 2004), page 1423-1428.
Topik: control; antidote mediated control; anticoagulant aptamer; in vivo

Ketersediaan

Perpustakaan Pusat (Semanggi) Nomor Panggil: NN9.3 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Patient safety and treatment outcome could be improved if physicians could rapidly the activity of therapeutic agents in their patients. Antidote control is the safest way to regulate drug activity, because unlike rapidly clearing drugs, control of the drug activity is independent of underlying patient physiology and co-morbidities. Until recently however there was no general method to discover antidote controlled drugs. Here we demonstrate that the activity and side effects by of a specific class of drugs, called aptamers, can be controlled by matched antidotes in vivo. The drug, an anticoagulant aptamer, systemically induces anticoagulant in pigs and inhibits thrombosis in murine models. The antidote rapidly reverses anticoagulation engendered by the drug, and prevents drug induced bleeding in surgically challenged animals. These results demonstrate that rationally designed drug antidote pairs can be generated to provide control over drug activities in animals.

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