Finding Time for Allosteric Interactions  

Oleh:

Wainer, Irving W.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Nature Biotechnology: The Science and Business of Biotechnology vol. 22 no. 11 (Nov. 2004), page 1376-1377.
Topik: INTERACTION; time; allosteric interactions

Ketersediaan

Perpustakaan Pusat (Semanggi) Nomor Panggil: NN9.3 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

A chromatographic method characterizes allosteric interactions between drugs an their targets. Drug discovery programs generally look for compounds that bind to orthosteric sites binding sites for the endogenous agoinst on target receptors. However, drug targets often have secondary, allosteric sites and binding at these sites can affect the affinity of agoinst and antagonists at the orthisteric site. Although the importance of allosteric modifiers is increasingly recognized, quantification of allosteric interactions has proven difficult. In this issue, chen and hage describe an alternative approach for determining the allosteric interactions of componds that bind to human serum albumin (HSA)...

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