Plant Cell Culture for The Production of Recombinant Proteins  

Oleh:

Hellwig, Stephan ; Drossard, Jurgen ; Twyman, Richard M. ; Fischer, Rainer

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Nature Biotechnology: The Science and Business of Biotechnology vol. 22 no. 11 (Nov. 2004), page 1415-1422.
Topik: PROTEIN; plant cell cultures; production; recombinant proteins

Ketersediaan

Perpustakaan Pusat (Semanggi) Nomor Panggil: NN9.3 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

The use of whole plants for the synthesis of recombinant proteins has received a great deal of attention recently because of advantages in economy, scalability and safety compared with traditional microbial and mammalian production systems. However, production systems that use whole plants lack several of the intrinsic benefits of cultured cells, including the precise control over growth conditions, batch to batch product consistency, a high level of containment and the ability to produce recombinant proteins in compliance with good manufacturing practice. Plant cell cultures combine the merits of whole plant systems with those of microbial and animal cell cultures, and already have an established track record for the production of valuable theurapeutic secondary metabolites. Although no recombinant proteins have yet been produced commercially using plant cell cultures, there have been many proof of principle studies and several companies are investigating the commercial feasibility of such production systems.

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