Neuro Cognitive and Electrophysiological Evidence of Altered Face Processing in Parents of Children With Autism : Implications for A Model of Abnormal Development of Social Brain Circuitry in Autism  

Oleh:

Dawson, Geraldine ; Schellenberg, Gerard D. ; Wijsman, Ellen ; Faja, Susan ; Estes, Annette ; Webb, Sara Jane ; Munson, Jeffrey

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Development and Psychopathology vol. 17 no. 3 (2005), page 679-698.
Topik: IMPLICATION; social brain; circuitry; autism; neuro cognitive; electro; physiological; face process; evidence; parents; implication; abnormal
Fulltext: 679.pdf (479.8KB)

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Perpustakaan Pusat (Semanggi) Nomor Panggil: DD21.9 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Neuroimaging and behavioral studies have shown that children and adults with autism have impaired face recognition. Individuals with autism also exhibit atypical event - related brain potentials to faces, characterized by a failure to show a negative component (N170) latency advantage to face compared to nonface stimuli and a bilateral, rather than right lateralized, pattern of N170 distribution. In this report, performance by 143 parents of children with autism on standardized verbal, visual – spatial, and face recognition tasks was examined. It was found that parents of children with autism exhibited a significant decrement in face recognition ability relative to their verbal and visual spatial abilities. Event - related brain potentials to face and nonface stimuli were examined in 21 parents of children with autism and 21 control adults. Parents of children with autism showed an atypical event - related potential response to faces, which mirrored the pattern shown by children and adults with autism. These results raise the possibility that face processing might be a functional trait marker of genetic susceptibility to autism. Discussion focuses on hypotheses regarding the neurodevelopmental and genetic basis of altered face processing in autism. A general model of the normal emergence of social brain circuitry in the first year of life is proposed, followed by a discussion of how the trajectory of normal development of social brain circuitry, including cortical specialization for face processing, is altered in individuals with autism. The hypothesis that genetic - mediated dysfunction of the dopamine reward system, especially its functioning in social contexts, might account for altered face processing in individuals with autism and their relatives is discussed.

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