Mempelajari Sifat Antikarsinogen Alamiah dari Turunan Fenol, Kumarin, Kromon, Flavon dan Iso Kumari  

Oleh:

Ibrahim, Sanusi ; Kusuma, Theresia Sita ; Mustafa, Djufri ; Refinel

Jenis: Article from Journal - ilmiah nasional
Dalam koleksi: Andalas: Jurnal Penelitian vol. 06 no. 15 (Jan. 1994), page 100-111.

Ketersediaan

Perpustakaan PKPM Nomor Panggil: A67 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

A Huckel molecular orbital has been used to study the anticarcinogenic properties of polycyclic (p) coumarins and chromones. Results of calculations of 52 polyvcyclic ammatic hydrocarbons (PAHs), carcinogenic or non carcinogenic, indicated that I110S1 of their chromones derivative were nOl chemoprotecrors, while thdr coumarins were anticarcinogen. Both p-coumarins and chromones inhibited aryl hydrocarbon hydroxylase (AHH) activity, blocked the interaction of diol epoxide with DNA, increased induced gluthatione S-transferase (GST)" had no effect on epoxide hydrolase (EH) activity. P-coumarins were also increase induced quin01ie reductase.

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