Effects of Hormone Therapy on Depressive Symptoms and Cognitive Functions in Women With Alzheimer Disease: A 12 Month Randomized, Double-Blind, Placebo-Controlled Study of Low-Dose Estradiol and Norethisterone  

Oleh:

Valen-Sendstad, Arnhild ; Engedal, Knut ; Stray-Pedersen, Babill ; Strobel, Carsten ; Barnett, Liv ; Nurminemi, Minna ; Meyer, Nicolay

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: The American Journal of Geriatric Psychiatry (keterangan: ada di ClinicalKey) vol. 18 no. 01 (Jan. 2012), page 11-20.
Topik: Hormone Therapy; Estradiol and Norethisterone; Alzheimer Disease; Apolipoprotein E; Cognition; Depressive Symptoms
Fulltext: A35 v18 n1 p11 kelik2022.pdf (219.16KB)

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Perpustakaan FK Nomor Panggil: A35.K Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Design: A 12-month randomized, double-blind, placebo-controlled study, stratified by apolipoprotein E (ApoE) genotype (with versus without the ?4 allele), duration of education (=9 versus >9 years), and age (=75 versus >75 years) performed during 2000–2004. Setting: Ambulatory memory clinic in a general hospital. Participants: Sixty-five female outpatients aged 65–89 years who met criteria for probable AD according to Diagnostic and Statistical Manual of Mental Disorders, fourth edition and International Classification of Diseases, tenth edition. Ten patients were excluded, resulting in 55 participants who had at least one posttreatment efficacy evaluation. Intervention: Randomly assigned to receive either 1-mg estradiol and 0.5-mg norethisterone or placebo once daily. Measurements: Cognitive variables were the Dementia Rating Scale, tests from Consortium to Establish a Registry for AD, Global Deterioration Scale (GDS) and Barthel Index. Results: When only treatment effects were compared by analysis of variance, there were nonsignificant differences between treatment groups for all efficacy variables. A linear model analysis, including stratifying factors in addition to treatment in the model, revealed a significant main effect on mood. The depressive symptoms were lower in the HT group than in the placebo group. Those treated with HT without the ApoE ?4 allele had better mood, Word Learning Memory score, and GDS score. Those in the HT group with a higher level of education obtained a better GDS score. Adverse events did not differ between the groups. Conclusion: HT interacts with ApoE genotype in women with AD. Women without an ApoE ?4 allele may get better mood and cognition with HT. HT may reduce depressive mood and give less cognitive decline.

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