Source of Genetic Aberrations in Human Embryonic Stem Cell: Common Fragile Sites and Replication Stress  

Oleh:

Williantarra, Ivanna

Jenis: Article from Journal - ilmiah nasional - tidak terakreditasi DIKTI
Dalam koleksi: Cermin Dunia Kedokteran vol. 44 no. 10 (Oct. 2017), page 701-705.
Topik: Common Fragile Sites; Genetic Aberrations; Human Embryonic Stem Cells; Replication Stress
Fulltext: C04 v44 n10 p701 kelik2017.pdf (322.38KB)

Ketersediaan

Perpustakaan FK Nomor Panggil: C04.K Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

The capability of human embryonic stem cell (hESC) to form all cell types of the human body has made them highly attractive for therapeutic applications. Amongst others, the usefulness of hESC in therapeutic applications highly relies on their genomic integrity and stability. However, hESCs are well documented to frequently acquire genetic changes such as aneuploidies, segmental deletions or amplifications, epigenetic changes, and mitochondrial DNA mutations. This leads to safety concerns regarding the use of hESC in cell-based therapies. Certain genetic or epigenetic changes in hESC might lead not only to altered differentiation potential, but also increased proliferation capacity. A major concern is that, in vivo, this change might lead to tumorigenesis. These review will highlight the reported genetic aberrations found in human embryonic stem cell as a result of replication stress caused by naturally occurring common fragile sites in hESC.

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