Evidence for Graft versus Tumour Effect after Allogeneic Stem Cell Transplantation for Leukemia and Lymphoma  

Oleh:

Kumaheri, Meutia Ayuputeri

Jenis: Article from Journal - ilmiah nasional - tidak terakreditasi DIKTI
Dalam koleksi: Cermin Dunia Kedokteran vol. 44 no. 11 (Nov. 2017), page 777-781.
Topik: Graft Rejection; Graft Versus Host Disease; Graft Versus Tumour Effect; Leukemia; Lymphoma; Stem Cell
Fulltext: C04 v44 n11 p777 kelik2017.pdf (450.34KB)

Ketersediaan

Perpustakaan FK Nomor Panggil: C04.K Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Haematopoietic stem cell transplantation (HSCT) has been commonly used in the treatment of haematopoietic malignancy as a rescue regiment to prevent bone marrow toxicity subsequent to high dose chemotherapy. The harmful effects are leading to graft versus host disease (GVHD). However, studies have shown that GVHD, T-cell dependent mechanisms, and NK cells in allogeneic stem cell transplantation contributed to a lower risk of disease relapse by a mechanism known as graft versus tumour (GVT) effect. Evidence of graft versus tumour (GVT) effect has allowed development of cancer therapy with less toxic chemotherapy to allow tumour eradication. This essay aims to discuss evidences of GVT effect after allogeneic stem cell transplantation in both leukaemia and lymphoma and examine future prospects of maximizing GVT effect in the treatment of both diseases.

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