Chronic Psychosocial Stress and Gut Health in Children: Associations With Calprotectin and Fecal Short-Chain Fatty Acids  

Oleh:

Michels, Nathalie ; Van de Wiele, Tom ; De Henauw, Stefaan

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Psychosomatic Medicine: Journal of Biobehavioral Medicine vol. 79 no. 08 (Oct. 2017), page 927-935.
Topik: Calprotectin; Psychosocial Stress

Ketersediaan

Perpustakaan FK Nomor Panggil: P01.K Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Objectives: The mechanisms underpinning the association between chronic stress and gut health are poorly understood. We aimed to investigate the relationship between bacterial produced short-chain fatty acids, gut barrier function, and stress measures. Methods: A fecal sample, hair sample, and questionnaire data were collected from 113 Belgian children (8–16 years old). Biological measures of stress included hair cortisol (most proximal 3 cm) and 5-minute heart rate variability (high frequency). Self-report measures of stress included emotional problems and negative events. Fecal calprotectin was determined as a marker of intestinal inflammation and an indirect indicator of gut barrier integrity. Fecal short-chain fatty acids (butyrate, propionate, acetate, valerate, isobutyrate, and isovalerate) were measured with gas chromatography. Linear regression analyses were adjusted for sex, age, socioeconomic status, body mass index, fiber intake, and protein intake. Results: Emotional problems were significantly associated with higher butyrate (ß = 0.263), valerate (ß = 0.230), isovalerate (ß = 0.231), and isobutyrate (ß = 0.233). Heart rate variability reflecting higher parasympathetic activity was related to lower valerate levels (ß = -0.217). Hair cortisol was not associated with the short-chain fatty acids. None of the stress measures and none of the fecal short-chain fatty acids were significantly related to fecal calprotectin. Conclusions: In healthy children, the impact of chronic stress is manifested more obviously in short-chain fatty acids than in intestinal inflammation as measured by levels of calprotectin. Despite the rather counterintuitive associations with butyrate, these results point to the need for further research on gut microbiome composition.

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