Correlation of Advanced Glycation End Products with Urinary Albumin Creatinin Ratio in Patients with Type 2 Diabetes Mellitus  

Oleh:

Anggraini, Debie ; Yaswir, Rismawati ; Lillah ; Husni

Jenis: Article from Journal - ilmiah nasional - terakreditasi DIKTI
Dalam koleksi: Indonesian Journal of Clinical Pathology and Medical Laboratory vol. 23 no. 02 (Mar. 2017), page 107-110.
Topik: Advanced Glycation End-Products; Urinary Albumin Creatinine Ratio; Diabetes Mellitus Type 2; Rasio Air Kemih Albumin Kreatinin
Fulltext: I01 v23 n2 p107 kelik2017.pdf (397.31KB)

Ketersediaan

Perpustakaan FK Nomor Panggil: I01.K Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Diabetic nephropathy is a microvascular complications of Diabetes Mellitus (DM), that progresses to End Stage Renal Disease (ESRD). Non-enzymatic glycation of free amino acids in chronic hyperglycemia produces advanced glycation end-products (AGEs). Advanced glycation end-products are metabolized in kidney and the accumulation induced glomerulus injury. Advanced glycation end-products is proven in pathogenesis of diabetic nephropathy. Microalbuminuria assay using Urinary Albumin Creatinine Ratio (UACR) is recommended to detect early diabetic nephropathy. The aim of this study was to determine the relationship of AGEs levels with UACR in patients with type 2 diabetes mellitus. This was an analytical study with cross-sectional design in 30 patients type 2 diabetes who met the inclusion and exclusion criteria and conducted blood tests at the Central Laboratory Instalation of Dr. M. Djamil Hospital Padang in May 2015–March 2016. Level of AGEs was performed by sandwich-ELISA method. Microalbuminuria was performed by imunoturbidimetri method. Data was analyzed by Spearman correlation test, significant if p<0.05. The mean levels of AGEs in patients with type 2 diabetes mellitus was 1052.18±750.25 ng/L. The mean value of UACR in patients with type 2 diabetes mellitus was 23.77±16.58 mg/g. Spearman correlation test showed a very strong correlation between the levels of AGEs and UACR with r=0.85 and p<0,05. There was a very strong correlation between AGEs levels with UACR in type 2 diabetes mellitus.

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