The Effcacy and Safety of Two Depo Medroxyprogesterone Acetate Injection Preparations as Contraception: An Open-Label, Randomized Controlled Study  

Oleh:

Rosdiana, Dewi Selvina ; Suherman, Suharti K. ; Affandi, Biran ; Baharrudin, Mohammad ; Gunadi, E. Rusdianto ; Amelia, Dwirani

Jenis: Article from Journal - ilmiah nasional - tidak terakreditasi DIKTI
Dalam koleksi: Cermin Dunia Kedokteran vol. 44 no. 05 (May 2017), page 314-317.
Topik: Hormonal Contraceptives; Medroxyprogesterone Acetate
Fulltext: C04 v44 n5 p314 kelik2017.pdf (245.05KB)

Ketersediaan

Perpustakaan FK Nomor Panggil: C04.K Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Background: Injectable hormonal contraceptives remain in extensive use in many developing countries, including Indonesia. This study was intended to compare the efficacy and safety of injectable hormonal contraception containing 150 mg/mL DMPA (drug A), that will be used for national Family Planning Program versus the innovator product (drug B). Methods: This study was an open-label, randomized, multicenter, 2-parallel group study, involving 400 women of childbearing age, who received drug A or drug B four times at 3-month interval. Results: No pregnancies occur in both groups after 4 injections of drug A or drug B over a period of 12 months, the pearl-index value for each group was zero. The incidence of adverse events between groups was comparable and tolerable, the most common events were amenorrhea, spotting, headache, and prolonged menstruation. Conclusion: Injectable DMPA (drug A) produced for National Family Planning program was comparable to the innovator DMPA drug (drug B) in terms of efficacy and safety.

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