Analgesic Effect of Combination of Essential Oil Curcuma xanthorriza Roxb. and Its Curcuminoids in Mice  

Oleh:

Pramono, Suwijiyo ; Wicaksono, Arko Jatmiko ; Yuniarti, Nunung

Jenis: Article from Journal - ilmiah internasional - tidak terdaftar di DIKTI
Dalam koleksi: Majalah Obat Tradisional vol. 20 no. 01 (Jan. 2015), page 16-23.
Topik: Ginger; Curcuminoid; Analgesic; Pain
Fulltext: Analgesic Effect of Combination of Essential Oil Curcuma xanthorriza Roxb. and Its Curcuminoids...16-23.pdf (367.92KB)

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Perpustakaan FK Nomor Panggil: M01.K Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

The study was conducted to determine the analgesic effect of the essential oil of ginger rhizome (Curcuma xanthorriza Roxb.), Kurkuminoid, and a combination of both. Extracting of kurkuminoid performed with ethyl acetate and hexane solvent. Essential oil obtained from the water-steam distillation. Analgesic test was conducted using formalin test (20µL 1% formalin, intraplantar) against the Swiss strain male mice (30?5g), age 2 months. Test group includes 0.5% CMC-Na P.O. (Negative control), indomethacin 4mg/kg P.O. and i.p. (Positive control), kurkuminoid 48mg/kg po, essential oil 24mg/kg po, po and their combinations Formalin injection was performed 1 hour after sample treatment. Data licking time taken in Phase I (0-5min) and phase II (10-30min) after formalin injection. Phase I indicate pain that occurs in the central nervous system (CNS), while phase II in the peripheral area. The results of the phase I trials show analgesic power of indomethacin po (4.96?3.26%) and ip (4.54?1.65%). Kurkuminoid and each essential oil (1.22?0.89%) and (28.8?8.48%), while the mixture (42.14?5.6%). Kurniawan (2007) reported that the magnitude of phase I of the power analgesic morphine 5mg/kg po was (69.68?2.17%). In phase II of essential oils have analgesic power of (74.63?1.97%), a mixture of essential oil (24mg/kg) and kurkuminoid (48mg/kg) has analgesic power of (67.56?0.59% ), indomethacin ip (49.46 ? 1.08%) and po (49.82 ? 0.91%), and kurkuminoid (44.80?1.46%).

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