HOMA-IR Index Evaluation on Antidiabetes Mellitus Effect of Andrographis paniculata (Burm. f.) Nees Purified Extract and Andrographolide  

Oleh:

Adriawan, Ignatius Ryan ; Andrie, Mohamad ; Susilowati, Rina ; Pramono, Suwidjiyo ; Nugroho, Agung Endro

Jenis: Article from Journal - ilmiah internasional - tidak terdaftar di DIKTI
Dalam koleksi: Majalah Obat Tradisional vol. 19 no. 01 (Jan. 2014), page 19-23.
Topik: Purified Extract of Andrographis Paniculata; Andrographolide; HOMA-IR Index; High Fat and Fructose Diet
Fulltext: M08 v19 n1 p19 kelik2017.pdf (724.67KB)

Ketersediaan

Perpustakaan FK Nomor Panggil: M01.K Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Diabetes mellitus type 2 was induced by high fat diet and fructose. The insulin resistance and hyperinsulinemia compensatory can be measured by index homeostatic model assessment – insulin resistance (HOMA-IR). Andrographis paniculata (Burm. f.) Nees is a traditional plant can be used to treat diabetes mellitus and the main active compound of this plant is Andrographolide. The objective of this study is to evaluate the effect of purified extract of Andrographis paniculata (Burm. f.) Nees and andrographolide on HOMA-IR index of High fat diet and fructose induced Wistar Rats. This study is quasi-experimental and data analysis was using Kruskal-Wallis test. The result showed that purified extract of Andrographis paniculata and andrographolide decreased HOMA-IR index. Purified extract of Andrographis paniculata 1303,8 mg/kg decreased HOMA-IR index by 82,05 %.

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