Positivity for Zinc Transporter 8 Autoantibodies at Diagnosis Is Subsequently Associated With Reduced ß-Cell Function and Higher Exogenous Insulin Requirement in Children and Adolescents With Type 1 Diabetes  

Oleh:

Juusola, Matilda ; Parkkola, Anna ; Harkonen, Taina ; Siljander, Heli ; Knip, Mikael

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Diabetes Care vol. 39 no. 01 (Jan. 2016), page 118-121.
Topik: Type 1 Diabetes
Fulltext: D05 v39 n1 p118 kelik2017.pdf (782.19KB)

Ketersediaan

Perpustakaan FK Nomor Panggil: D05.K Non-tandon: 2 (dapat dipinjam: 1) Tandon: tidak ada

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OBJECTIVE This study assessed the relationship between autoantibodies against zinc transporter 8 (ZnT8A) and disease characteristics at diagnosis of type 1 diabetes and during the first 2 years. RESEARCH DESIGN AND METHODS Children, younger than 15 years of age (n = 723) who were newly diagnosed with diabetes, were analyzed for ZnT8A, other diabetes-associated autoantibodies, HLA DR-DQ alleles, and metabolic status, which was monitored by pH, plasma glucose, and occurrence of ketoacidosis at diagnosis and through follow-up of C-peptide concentrations, exogenous insulin dose, and glycosylated hemoglobin for 2 years after the diagnosis. RESULTS ZnT8A positivity was detected in 530 children (73%). Positivity for ZnT8A was associated with older age (median 8.9 vs. 8.2 years, P = 0.002) and more frequent ketoacidosis (24% vs. 15%, P = 0.013). Children carrying the HLA DR3 allele were less often ZnT8A positive (66% vs. 77%, P = 0.002) than others. ZnT8A-positive children had lower serum C-peptide concentrations (P = 0.008) and higher insulin doses (P = 0.012) over time than their ZnT8A-negative peers. CONCLUSIONS Positivity for ZnT8A at diagnosis seems to reflect a more aggressive disease process before and after diagnosis.

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