Structure–Antimicrobial Properties Study of Some Dibasic Phenylcarbamic Acid Esters  

Oleh:

Csollei, Jozef ; Malík, Ivan ; Bukovsky, Marian

Jenis: Article from Journal - ilmiah nasional - terakreditasi DIKTI
Dalam koleksi: Indonesian Journal of Pharmacy vol. 27 no. 01 (Jan. 2016), page 53-58.
Topik: Dibasic Phenylcarbamic Acid Esters; Escherichia Coli; Hydrogen Bonding; Lipophilicity
Fulltext: I03 v27 n1 p53 kelik2017.pdf (668.43KB)

Ketersediaan

Perpustakaan FK Nomor Panggil: I03.K Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

Due to worldwide phenomenon of microbial resistance to commonly used therapeutic agents, antibiotics and antifungals, dibasic di-/trimethylphenylcarbamic acid esters 1–3, a non--traditional series of potential antimicrobials, has been in vitro evaluated against chosen gram-positive (Staphylococcus aureus) and gram-negative (Escherichia coli) bacterial strains as well as against yeast (C. albicans) by the minimum inhibitory concentration (MIC) assay. Taking into consideration chemical structure of tested derivatives, the incorporation of more than one protonated atom of nitrogen into salt forming fragment positively influenced the activity against E. coli. On the contrary, the presence of one or more methyl groups instead of 3-alkoxy side chain attached to lipophilic aromatic moiety has not found to be favorable structural feature. In entire set of inspected compounds, the most promising results have been found for the compound 3, chemically 1-[3-piperidinium-1-yl-2-({[(2,4,6-trimethylphen-yl)amino]carbonyl}oxy)propyl]piperidinium dichloride, against E. coli with the MIC=1.56mg/mL.

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