Determination of Sibutramine Adulterated in Herbal Slimming Products Using TLC Densitometric Method  

Oleh:

Hayun ; Maggadani, Baitha P. ; Amalina, Nurul

Jenis: Article from Journal - ilmiah nasional - terakreditasi DIKTI
Dalam koleksi: Indonesian Journal of Pharmacy vol. 27 no. 01 (Jan. 2016), page 15-21.
Topik: Sibutramine HCl; Herbal Slimming Products; TLC; Densitometry; Validation Method
Fulltext: I03 v27 n1 p15 kelik2017.pdf (717.03KB)

Ketersediaan

Perpustakaan FK Nomor Panggil: I03.K Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

Determination of sibutramine adulterated in herbal slimming product using thin layer chromatography (TLC) densitometric method with TLC silica gel 60 F254 aluminium plate as stationary phase and mixture of toluen-diethylamine (10:0.3) as mobile phase has been developed. The calibration curve in the concentration range of 0.50 to 5.00µg/spot showed good linier relationship (r2 = 0.9986). The limit of detection and quantitation (LOD and LOQ) were 217.5ng and 724.9ng/spot, respectively. The method gave satisfactory specificity, linierity, precision and accuracy validation criteria and was applied for determination of sibutramine in herbal slimming products obtained from several drugstrores in Depok City, West Java, Indonesia. Results of the determination showed that six of seven samples analyzed were detected containing sibutramine HCl with the concentration of 2.45-26.24mg in a single dosage of slimming herbal products.

Opini Anda

Klik untuk menuliskan opini Anda tentang koleksi ini!

Kembali