Analysis of Active Compounds in Blood Plasma of Mice After Inhalation of Cajuput Essential Oil (Melaleuca Leucadendron L.)  

Oleh:

Muchtaridi ; Tjiraresmi, Ami ; Febriyanti, Riska

Jenis: Article from Journal - ilmiah nasional - terakreditasi DIKTI
Dalam koleksi: Indonesian Journal of Pharmacy vol. 26 no. 04 (Oct. 2015), page 219-227.
Topik: Cajuput; Essential Oils; Inhalation; SPE; GC-MS
Fulltext: I03 v26 n4 p219 kelik2017.pdf (750.83KB)

Ketersediaan

Perpustakaan FK Nomor Panggil: I03.K Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

The research is intended for the determination of volatile compounds of cajuput oil (Melaleuca leucadendron L.) in a group of mice (3 mice) after inhaling 1mL cajuput oil for 1/2, 1 and 2h(s). The blood plasma of three mice was collected in heparin tube, and the volatile compounds were isolated and concentrated using C-18 Solid Phase Extraction (SPE) column with methanol and bidistilled water mixture (60:40) as the solvent. The analysis was carried out by GC/MS. The results showed that there were 52 compounds in the cajuput oil, especially 1,8-cineole,?-terpineol, ?-pinene, ?-pinene, ?-myrcene, 4-terpineol, linalool, ?-terpinene, and terpinolene. The major compound identified in blood plasma of mice was 1,8-cineole. Half an hour after 1mL inhalation of cajuput oil per mouse, the concentration of 1,8-cineole identified was 41.5?g/mL, while 1 and 2h after 1mL inhalation of cajuput oil, the level of 1,8-cineole in blood plasma of 3 mice was 646.9?g/mL and 138.0?g/mL in blood plasma of each mouse. Other compounds identified were ?-terpineol, 4-terpineol linalool, terpenyl acetate and hydrocarbon terpenes. Concentrations of target compounds in the blood plasma were relatively in low level (?g/mL). In conclusion, the volatile compounds of 4-terpineol, linalool, ?-terpineol and 1,8-cineol that identified in blood plasma of mice after inhalation of the cajuput oils might correlate with depressive characteristics of essential oil given by inhalation.

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