In Vitro Antidiabetic and In Vivo Antidiarrheal Activity of Oncoba Spinosa Roots  

Oleh:

Kumar M., Prasanth ; Suba V. ; Ramireddy B. ; Babu P., Srinivas

Jenis: Article from Journal - ilmiah nasional - terakreditasi DIKTI
Dalam koleksi: Indonesian Journal of Pharmacy vol. 26 no. 03 (Jul. 2015), page 121-128.
Topik: In Vivo; In Vitro; Antidiabetic; Antidiarrheal; Oncoba Spinosa; Roots
Fulltext: I03 v26 n3 p121 kelik2017.pdf (803.8KB)

Ketersediaan

Perpustakaan FK Nomor Panggil: I03.K Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

The different extracts of Oncoba spinosa (Flacourtiaceae) were screened for in vitro antidiabetic activity. Of all the extracts tested, ethanolic extract showed highest a-amylase inhibition ranging from 8.64+0.66% to 79.94+0.65% and a-glucosidase inhibition ranging from 14.12+0.51% to 78.68+0.36% when studied at concentrations 62.5-1000µg/mL. The ethanolic extract was subjected to antidiarrheal activity and diarrheal severity was reduced significantly by 15.81% in 100mg/kg group, 30.45% in 200mg/kg group and 74.37% in 400mg/kg group in castor oil induced diarrhea model. In castor oil induced enteropooling, the extract at doses 200mg/kg and 400mg/kg showed 33.46% and 42.44% inhibition of intestinal accumulation. In the charcoal meal test, the distance travelled by charcoal meal was significantly reduced by the extract at doses 200mg/kg and 400mg/kg (P<0.01). The overall results tend to suggest the antidiabetic and antidiarrheal activities of Oncoba spinosa.

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