Optimization of Extraction Conditions for Andrographolide using Fractional Factorial Design  

Oleh:

Rafi, Mohamad ; Darusman, Latifah Kosim ; Nurasiah, Eulis Siti ; Syafitri, Utami Dyah

Jenis: Article from Journal - ilmiah nasional - terakreditasi DIKTI
Dalam koleksi: Indonesian Journal of Pharmacy vol. 25 no. 03 (Jul. 2014), page 145-152.
Topik: Andrographolide; King of Bitter; Andrographis Paniculata; Fractional Factorial Design
Fulltext: I03 v25 n3 p145 kelik2017.pdf (658.44KB)

Ketersediaan

Perpustakaan FK Nomor Panggil: I03.K Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Andrographolide is a major bioctive compound found in king of bitter (Andrographis paniculata). In this study, the extraction method and its condition were investigated in order to get an extract with maximum amount of andrographolide by comparing three other extraction methods, i.e. maceration, soxhletation and ultrasonication and also determination for the optimum condition of the selected extraction method. The highest andrographolide amount was found by maceration, so this method was choosen for further optimization of extraction condition. The optimum condition based on the prediction amount from 27 factor combinations was obtained in 360 times of extraction time, 2g/100mL of sample to solvent ratio, and 3fold of extraction frequency with prediction of andrographolide amount was 3.50%. While by using prediction profile, the optimum condition was obtained in 360min of extraction time, 2 g/100mL of sample and solvent ratio, and 4 times of extraction frequency with the amount was 3.47-3.74%.

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