Epigenetic Germline Inheritance of Diet-Induced Obesity and Insulin Resistance  

Oleh:

Huypens, Peter ; Sass, Steffen ; Wu, Moya ; Dyckhoff, Daniela ; Tschop, Matthias

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Nature Genetics vol. 48 no. 05 (May 2016), page 497-499.
Topik: Diabetes; Metabolic Disorders

Ketersediaan

Perpustakaan FK Nomor Panggil: N12.K Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

There is considerable controversy regarding epigenetic inheritance in mammalian gametes. Using in vitro fertilization to ensure exclusive inheritance via the gametes, we show that a parental high-fat diet renders offspring more susceptible to developing obesity and diabetes in a sex- and parent of origin–specific mode. The epigenetic inheritance of acquired metabolic disorders may contribute to the current obesity and diabetes pandemic.

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