The Genomic Basis of Parasitism in the Strongyloides Clade of Nematodes  

Oleh:

Hunt, Vicky L. ; Isheng J. Tsai ; Coghlan, Avril ; Reid, Adam J. ; Holroyd, Nancy

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Nature Genetics vol. 48 no. 03 (Mar. 2016), page 299-307.
Topik: Gene Expression; Genome Informatics; Genomics Sequencing
Fulltext: N12 v48 n3 p299 kelik2017.pdf (2.43MB)

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Perpustakaan FK Nomor Panggil: N12.K Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Soil-transmitted nematodes, including the Strongyloides genus, cause one of the most prevalent neglected tropical diseases. Here we compare the genomes of four Strongyloides species, including the human pathogen Strongyloides stercoralis, and their close relatives that are facultatively parasitic (Parastrongyloides trichosuri) and free-living (Rhabditophanes sp. KR3021). A significant paralogous expansion of key gene families—families encoding astacin-like and SCP/TAPS proteins—is associated with the evolution of parasitism in this clade. Exploiting the unique Strongyloides life cycle, we compare the transcriptomes of the parasitic and free-living stages and find that these same gene families are upregulated in the parasitic stages, underscoring their role in nematode parasitism.

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