Regulators of Genetic Risk of Breast Cancer Identified by Integrative Network Analysis  

Oleh:

Castro, Mauro A. A. ; de Santiago, Ines ; Campbell, Thomas M. ; Vaughn, Courtney ; Hickey, Theresa E. ; Ross, Edith ; Tilley, Wayne D. ; Markowetz, Florian ; Ponder, Bruce A. J. ; Meyer, Kerstin B.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Nature Genetics vol. 48 no. 01 (Jan. 2016), page 12-21.
Topik: Breast Cancer; Functional Genomics

Ketersediaan

Perpustakaan FK Nomor Panggil: N12.K Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

Genetic risk for breast cancer is conferred by a combination of multiple variants of small effect. To better understand how risk loci might combine, we examined whether risk-associated genes share regulatory mechanisms. We created a breast cancer gene regulatory network comprising transcription factors and groups of putative target genes (regulons) and asked whether specific regulons are enriched for genes associated with risk loci via expression quantitative trait loci (eQTLs). We identified 36 overlapping regulons that were enriched for risk loci and formed a distinct cluster within the network, suggesting shared biology. The risk transcription factors driving these regulons are frequently mutated in cancer and lie in two opposing subgroups, which relate to estrogen receptor (ER)+ luminal A or luminal B and ER- basal-like cancers and to different luminal epithelial cell populations in the adult mammary gland. Our network approach provides a foundation for determining the regulatory circuits governing breast cancer, to identify targets for intervention, and is transferable to other disease settings.

Opini Anda

Klik untuk menuliskan opini Anda tentang koleksi ini!

Kembali