MALDI-TOF dan SELDI-TOF Mass Spectrometry dengan Throughput Tinggi untuk Analisis Proteomik Profil Protein dari Petanda Biologis  

Oleh:

Andayaningsih, Trinovia ; Siti Muchayat P.

Jenis: Article from Journal - ilmiah nasional - terakreditasi DIKTI
Dalam koleksi: Indonesian Journal of Clinical Pathology and Medical Laboratory vol. 22 no. 02 (Mar. 2016), page 194-199.
Topik: MALDI-TOF; SELDI-TOF; Mass Spectrometry; High Throughput; Proteomic; Protein Profiling; Biomarker; Daya Pengerjaan yang Berlebihan; Protein Kecil; Peptida; Penampangan Protein; Petanda Biologis
Fulltext: I01 v22 n2 p194 kelik2017.pdf (307.1KB)

Ketersediaan

Perpustakaan FK Nomor Panggil: I01.K Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

In recent years, proteomic approach has been widely used for diagnosing the diseases and matrix assisted laser desorption / ionization- time of the flight (MALDI-TOF) mass spectrometry and its modification, surface enhanced laser desorption /ionization-time of flight (SELDI-TOF) mass spectrometry have became very promising diagnostic tools. High throughputs and relative simplicity of these technologies attracted the researchers to know the biomarkers of specific diseases by analyzing specimens of serum/plasma and other body fluids. Analyzing plasma specimens by MALDI/SELDI TOF mass spectrometry provides new information especially about small protein and peptides in high abundance. Protein profilings, resulting by these technologies provide higher sensitivity and specificity values than current biomarkers. Knowing how these principle tools work and its promising application to early detection of specific diseases is the aim of writing this paper.

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