Kadar Surfactant Protein-D Serum pada Pasien Penyakit Paru Obstruktif Kronis Berkebahayaan Kambuhan Rendah dan Tinggi  

Oleh:

Nurhayati, Dewi ; Parwati, Ida ; Rostini, Tiene ; Yuwono, Arto

Jenis: Article from Journal - ilmiah nasional - terakreditasi DIKTI
Dalam koleksi: Indonesian Journal of Clinical Pathology and Medical Laboratory vol. 22 no. 02 (Mar. 2016), page 168-175.
Topik: COPD; Serum SP-D Level; COPD Combined Assessment GOLD Criteria 2011; Low Risk of Exacerbation; High Risk of Exacerbation; PPOK; Tingkat Serum SP-D; Kebahayaan Kambuhan Rendah; Kebahayaan Kambuhan Tinggi
Fulltext: I01 v22 n2 p168 kelik2017.pdf (164.71KB)

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Perpustakaan FK Nomor Panggil: I01.K Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Chronic obstructive pulmonary disease (COPD) cause high morbidity and mortality worldwide. The exacerbations in chronic obstructive pulmonary disease accelerate the decline in lung function and health status, as well as in increasing the treatment cost and mortality risk. The spiro metric measurement has several limitations in assessing the severity as well as the exacerbation risk in COPD patients. Currently, has been available serum surfactant protein-D, a marker of lung inflammation and lung tissue damage. This protein is produced by the alveolar type II cells and the Clara cells that play role in maintaining the lung stability and pulmonary immune system. The increased level of serum SPD indicates that there is lung epitihelial leakage in line with COPD severity increment and reflected in COPD exacerbation level of risk according to combined COPD assessment GOLD criteria of the year 2011. The aim of this study was to know the differences of SP-D serum levels between low and high risk of exacerbation in COPD patients by determination them. This study was conducted from March to July 2014. The subjects of this study were COPD patients diagnosed by spiro metric measurement. The research was conducted in comparative analytic way with a cross sectional study design. The statistical analysis was performed using Mann-Whitney non-parametric test. The subjects were 62 COPD patients. The SP-D serum level at low risk of exacerbation group differ significantly compared to the high risk exacerbation group, 1.8–68.4 ng/mL and 3.36–116.4 ng/mL respectively (P=0.018). Based on this study it can be concluded that the SP-D serum levels were higher in COPD patients with high risk exacerbation than the lower risk one. The SP-D serum levels may be considered as a specific marker of lung tissue injury to assess the risk of the exacerbation in COPD patients.

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