Interleukin-4 dan Interferon Gamma di Nefritis Lupus: Hubungan Aktivitas Penyakit Serta Kekambuhan  

Oleh:

Achamar, Torajasa ; Farida, Dany ; Susianti, Hani ; Handono, Kusworini ; Rastini, Ati ; Gunawan, Atma

Jenis: Article from Journal - ilmiah nasional - terakreditasi DIKTI
Dalam koleksi: Indonesian Journal of Clinical Pathology and Medical Laboratory vol. 22 no. 02 (Mar. 2016), page 141-146.
Topik: Lupus Nephritis; Interleukin-4; Interferon-Gamma; Disease Activity; Flare Up; Nefritis Lupus; Aktivitas Penyakit; Kekambuhan
Fulltext: I01 v22 n2 p141 kelik2017.pdf (197.66KB)

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Perpustakaan FK Nomor Panggil: I01.K Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Sampling for urinalysis to see the activity and the degree of recurrence of Lupus Nephritis (LN) is very difficult. New biomarkers that are more simple, sensitive, specific and non-invasive in assessing the activity of the LN need to be investigated. Interleukin-4 (IL-4) and interferon gamma (IFN-?) were implicated to LN process. Urine samples from 17 LN patients were taken every month for 6 (six) months to examine the level of uIL-4, uIFN-?, activity and recurrence of LN. Significant differences were observed in the uIFN-? levels between the active and inactive LN groups (p=0.012), but not in uIL-4 levels (p=0.187). Correlations between each biomarker and renal domain score were weak (r=0.201, p=0.042 for uIL-4; r=0.268, p=0.006 for uIFN-?). Significant differences were also found in the uIL-4 and uIFN-? levels against LN recurrence (p=0.033; p=0.017). The best cut off values to assess recurrences and activity of LN were 8.17 pg/mL for uIL-4 showed a sensitivity of 74%, specificity 71%, NPV 90%, PPV 42% to assess recurrences and to assess activity of LN showed sensitivity 46%, specificity 75%, NPV 48%, PPV 78%. The cut off 18.58 pg/mL for uIFN-? to predict recurrent and assess the activity of LN showed sensitivity 68%%, specificity 70%, NPV 88%, PPV 40% to predict the recurrent and to assess the activity of LN showed sensitivity 57%, specificity 64%, NPV 49%, PPV 73%. Based on the research, uIL-4 and uIFN-? are not good enough to predict recurrence and activity of LN.

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