Penilaian Uji Troponin I dengan Point of Care Testing  

Oleh:

Febriana, Sheila ; Nurulita, Asvin ; Bahrun, Uleng

Jenis: Article from Journal - ilmiah nasional - terakreditasi DIKTI
Dalam koleksi: Indonesian Journal of Clinical Pathology and Medical Laboratory vol. 22 no. 02 (Mar. 2016), page 114-118.
Topik: Troponin I; Acute Coronary Synndrome; Point of Care Testing; Darah Lengkap; Whole Blood
Fulltext: I01 v22 n2 p114 kelik2017.pdf (161.04KB)

Ketersediaan

Perpustakaan FK Nomor Panggil: I01.K Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Troponin I is a cardiac biomarker recomended by The Third Global Myocardial Infarction Task Force World Health Organisation (WHO). Troponin plays a central role as a relevant biomarker that require reliable samples, methods, device and efficiency of time. Selecting the device, methods and sample used in the assay may affect the results and turn arround time. The aim of this study is to know troponin I result using Point of care Testing device with a flourescence immunoassay methods using whole blood and laboratorybased analysis device with Enzyme-Linked Fluorescent Assay (ELFA) methods using serum by evaluation. Cross sectional study was held on 50 subjects in Wahidin Sudirohusodo hospital during the period between July-August 2015, those who suspected suffering acute coronary syndome (ACS) and underwent troponin I test ordered by the physician and also had whole blood sample. The subjects are around 51.96±12.80 year old and most of them are men (62%). The mean consentration of troponin I with laboratoric-based analysis is 0.50±1.69 µg/L and with POCT is 0.51±1.77. The Pearson correlation test shows the correlation (r) is 0.99 with the p value is <0.001. Bland and Altman methods show the mean difference between two assays is 0.014µg/L (95% confidence interval, -0.015; 0.043) with the limit of agreement -0.19 to 0.22. Based on this study, it can be concluded that troponin I assay using POCT device can be used to support ACS diagnosis precisely and rapidly. It is suggested to perform futher study with concern on the patient’s clinical condition as well as the diagnosis, so it can evaluate the device performance to measure troponin I levels consistently with the clinical condition.

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