Income and Markers of Immunological Cellular Aging  

Oleh:

Aiello, Allison E. ; Feinstein, Lydia ; Dowd, Jennifer B. ; Pawelec, Graham ; Derhovanessian, Evelyna ; Galea, Sandro ; Uddin, Monica ; Wildman, Derek E. ; Simanek, Amanda M.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Psychosomatic Medicine: Journal of Biobehavioral Medicine vol. 78 no. 06 (Jul. 2016), page 657-666.
Topik: Cytomegalovirus; Immunity; Aging; Immunosenescence

Ketersediaan

Perpustakaan FK Nomor Panggil: P01.K Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

Objective: Socioeconomic disadvantage may contribute to poor health through immune-related biological mechanisms. We examined the associations between socioeconomic status, as measured by annual household income, and T-cell markers of aging, including the ratios of CD4 and CD8 effector cells to naïve cells (E/N ratio) and the CD4/CD8 T-cell ratio. We hypothesized that participants with a lower income would have higher E/N ratios and lower CD4/CD8 ratios compared with participants with a higher income, and that these associations would be partially mediated by elevated cytomegalovirus (CMV) IgG antibody levels, a virus implicated in aging and clonal expansion of T cells. Methods: Data were from 79 individuals who participated in the population-based Detroit Neighborhood Health Study. We used linear regression to quantify the association between a $10,000 decrease in income and each ratio outcome. Results: After adjustment for age, sex, race, smoking, medication use, and lifetime history of mental health conditions, lower income was associated with a 0.41 (95% confidence interval = 0.09–0.72) log-unit increase in the CD4 E/N ratio and a 0.20 (95% confidence interval = 0.02–0.39) log-unit increase in the CD8 E/N ratio. CMV immunoglobulin G antibody level partially mediated these associations. Conclusions: Our study suggests that low socioeconomic status is associated with immunological aging as measured by the E/N ratio and that impaired immune control of CMV may partially mediate these associations.

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