Improved Implantation Rates of Day 3 Embryo Transfers with the Use of an Automated Time-Lapse–Enabled Test to Aid in Embryo Selection  

Oleh:

Adamson, G. David ; Abusief, Mary E. ; Palao, Lourella ; Witmer, Jennifer ; Palao, Lonyl M. ; Gvakharia, Marina

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Fertility and Sterility (keterangan: ada di ClinicalKey) vol. 105 no. 02 (Feb. 2016), page 369-375.
Topik: Embryo Selection; Time-Lapse; Morphology; Automated; Prognostic Test
Fulltext: F02 v105 n2 p369 kelik2016.pdf (795.26KB)

Ketersediaan

Perpustakaan FK Nomor Panggil: F02.K Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

Objective: To determine if an automated time-lapse test (TL-test) combined with traditional morphology for embryo selection and day 3 transfer results in improved clinical outcomes. Design: Prospective concurrent-controlled pilot study. Setting: IVF clinic and laboratory. Patient(s): A total of 319 female patients <41 years old, with day 3 embryo transfer, fewer than three failed IVF cycles, and at least four zygotes (2-pronuclear) on day 1. Intervention(s): Automated time-lapse embryo assessment combined with morphologic assessment in the study (test) group compared with morphologic assessment only (control group). Main Outcome Measure(s): Embryo implantation, pregnancy, and multiple pregnancy rates. Subanalysis of implantation potential of embryos based on the TL-test (TL-high vs. TL-low) scores. Result(s): Implantation and clinical pregnancy rates were significantly higher in the test group compared with the control group (implantation rates 30.2% vs. 19.0%, clinical pregnancy rates 46.0% vs. 32.1%, respectively). Multiple pregnancy rates were not statistically different (26.7% vs. 18.3%). Test group patients receiving at least one TL-high embryo had significantly higher implantation rates than patients receiving only TL-low embryos (36.8% vs. 20.6%). TL-high compared with TL-low embryos had significantly higher implantation rates (44.7% vs. 20.5%). Among morphologically good embryos, TL-high embryos were more likely to implant than TL-low embryos (44.1% vs. 20.6%). Conclusion(s): This is the first report demonstrating improved implantation rates in patients receiving day 3 embryo transfers based on the combined use of a TL-test along and traditional morphology. Our findings confirm that the noninvasive TL-test adds valuable information to traditional morphologic grading.

Opini Anda

Klik untuk menuliskan opini Anda tentang koleksi ini!

Kembali