Correlation Between Heat Shock Protein (Hsp) 70 Level and Left Ventricular Dysfunction and its Effect on Cardiovascular and Rehospitalization Incidence in Patients With Acute Coronary Syndrome  

Oleh:

Andayani, Ni Gusti Putu Sri ; Ariyanti, Dwi ; Putranto, J Nugroho Eko

Jenis: Article from Journal - ilmiah nasional - terakreditasi DIKTI
Dalam koleksi: Folia Medica Indonesiana vol. 51 no. 2 (2015), page 125-131.
Topik: Acute coronary syndrome; HSP70; LV function; heart failure; mortality and rehospitalization
Fulltext: download-fullpapers-fmi58a20e69f1full.pdf (119.54KB)

Isi artikel

HSP70 role in coronary artery disease (CAD) is still debated. Some studies showed that it played a role as a danger signal initiates inflammation response involved in left ventricular (LV) remodeling that result in LV dysfunction and heart failure. Our study aimed to prove the association between extracellular HSP70 level and LV dysfunction and its effect on cardiovascular events and rehospitalization in ACS patients Sixty patients with ACS in Dr. Soetomo Hospital between July and October 2013 were followed up for 6 months. The patients were stratified into low and high HSP70 group. HSP70 was measured at the initial admission while LV function by echocardiography was assessed at the initial admission and compared after 3 months of follow up. Kaplan-Meier survival analysis was done to describe heart failure, mortality, and rehospitalization caused by cardiovascular disease during 6 months follow-up in both groups. The HSP70 level was significantly correlated with LVEF at admission and after 3 months (r=-0.689; p<0.001; r=-0.705; p<0.001), LV PW MPI at admission and after 3 months (r=0.507; p<0.001; r=0.675; p<0.001), LV TDI MPI at admission and after 3 months (r=0.588; p<0.001; r=0.672; p<0.001), DT at admission (r=-0.322; p=0.012), E/A at admission (r=0.373; p=0.003), E/E’ at admission and after 3 months (r=324; p=0.011; r=0.382; p=0.006). In our study, higher HSP70 levels were associated with an increased heart failure (log-rank test, p<0.001) during the 6 months follow-up period. Kaplan-Meier survival analysis showed HR of heart failure based on the HSP70 median was 5.35 (CI 95% (2.25-12.7); p<0.001), HR of mortality 3.096 (CI95% (0.838-11.444); p=0.09) and HR of rehospitalization 85.685 (CI 95% (0.059-125012.62); p=0.231). In conclusion, extracellular HSP70 level associated with LV function and heart failure in the patients with ACS. (FMI 2015;51:125-

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