Chronic Endometritis in Women with Recurrent Pregnancy Loss and Recurrent Implantation Failure: Prevalence and Role of Office Hysteroscopy and Immunohistochemistry in Diagnosis  

Oleh:

Bouet, Pierre-Emmanuel ; Hady El Hachem ; Monceau, Elise ; Gariepy, Gilles ; Kadoch, Isaac-Jacques ; Sylvestre, Camille

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Fertility and Sterility (keterangan: ada di ClinicalKey) vol. 105 no. 01 (Jan. 2016), page 106–110.
Topik: Chronic Endometritis; Recurrent Pregnancy Loss; Implantation Failure; Plasma Cells; Office Hysteroscopy
Fulltext: F02 v105 n1 p106 kelik2016.pdf (533.45KB)

Ketersediaan

Perpustakaan FK Nomor Panggil: F02.K Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

Objective: To determine the prevalence of chronic endometritis (CE) in patients with recurrent implantation failure (RIF) after IVF and unexplained recurrent pregnancy loss (RPL). Design: Prospective observational study between November 2012 and March 2015. Setting: University-affiliated private IVF clinic. Patient(s): Women with RIF after IVF (group 1) and unexplained RPL (group 2). Intervention(s): Office hysteroscopy followed by an endometrial biopsy was performed as part of the workup for RIF and RPL. The diagnosis of CE was histologically confirmed using immunohistochemistry stains for syndecan-1 (CD138). Main Outcome Measure(s): The prevalence of CE in each group and the sensitivity/specificity of office hysteroscopy in the diagnosis of CE. Result(s): Ninety-nine patients were included (46 in group 1 and 53 in group 2). The mean age was 36.3 ± 4.9 years in group 1 and 34.5 ± 4.9 years in group 2. Five biopsies were uninterpretable (three in group 1 and two in group 2) because of insufficient specimen. The prevalence of CE was 14% (6/43) in group 1 and 27% (14/51) in group 2. The sensitivity and specificity of office hysteroscopy in the diagnosis of CE were 40% (8/20) and 80% (59/74), respectively. Conclusion(s): We found a high prevalence of immunohistochemically confirmed CE in women with RIF and RPL. Office hysteroscopy is a useful diagnostic tool but should be complemented by an endometrial biopsy for the diagnosis of CE.

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