Elevated Serum Interleukin-1ß Levels and Interleukin-1ß-to-Interleukin-1 Receptor Antagonist Ratio 1 Week after Embryo Transfer are Associated with Ectopic Pregnancy  

Oleh:

Lekovich, Jovana ; Witkin, Steven S. ; Doulaveris, Georgios ; Orfanelli, Theofano ; Shulman, Brittney ; Pereira, Nigel ; Rosenwaks, Zev ; Spandorfer, Steven D.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Fertility and Sterility (keterangan: ada di ClinicalKey) vol. 104 no. 05 (Nov. 2015), page 1190–1194.
Topik: Interleukin 1ß; Interleukin-1 Receptor Antagonist; Ectopic Pregnancy; IVF
Fulltext: F02 v104 n5 p1190 kelik2016.pdf (213.1KB)

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Perpustakaan FK Nomor Panggil: F02.K Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Objective: To investigate whether interleukin-1ß (IL-1ß) and interleukin-1 receptor antagonist (IL-1RA) serum levels in the early luteal phase differ in IVF cycles that result in an ectopic pregnancy (EP) when compared with other outcomes. Design: Retrospective cohort. Setting: Not applicable. Patient(s): A total of 307 women whose serum samples were available, with the following IVF outcomes: 103 live births, 80 negative pregnancy tests, 52 biochemical pregnancies, 47 EPs, and 25 miscarriages. Intervention(s): Serum samples were obtained on cycle days 24 and 28 (cycle day 14 = day of egg retrieval). Levels of IL-1ß and IL-1RA were determined by quantitative ELISA performed by blinded personnel. Main Outcome Measure(s): IL-1ß and IL-1RA levels, IL-1ß-to-IL-1RA ratio versus cycle outcome. Result(s): The IL-1ß levels were predictive of an EP. At cycle days 24 and 28 the mean IL-1ß levels were higher in patients with an EP (127.1 pg/mL and 166.9 pg/mL, respectively) than in women with any other IVF outcome (15.8–55.3 pg/mL and 14.8–75.5 pg/mL, respectively). At cycle day 24 the IL-1ß-to-IL-1RA ratio was 0.18 in the ectopic group versus 0.01–0.09 in the other groups. Conclusion(s): Elevated IL-1ß levels and IL-1ß-to-IL-1RA ratio as early as 4 days before the first pregnancy test are associated with an EP. If confirmed by prospective studies, clinical application of these findings could potentially improve EP detection.

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