Putative Role for Insulin Resistance in Depression Risk in Polycystic Ovary Syndrome  

Oleh:

Greenwood, Eleni A. ; Pasch, Lauri A. ; Shinkai, Kanade ; Cedars, Marcelle I. ; Huddleston, Heather G.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Fertility and Sterility (keterangan: ada di ClinicalKey) vol. 104 no. 03 (Sep. 2015), page 707–714.
Topik: Polycystic Ovary Syndrome; Depression; Insulin Resistance
Fulltext: F02 v104 n3 p707 kelik2016.pdf (367.06KB)

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Perpustakaan FK Nomor Panggil: F02.K Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Objective: To evaluate whether insulin resistance is associated with depression risk in women with polycystic ovary syndrome (PCOS), independent of other factors, including body mass index (BMI). Design: Cross-sectional. Setting: Tertiary university center. Patient(s): A total of 301 women, aged 14–52 years, with PCOS by Rotterdam criteria, consecutively examined between 2006 and 2013. Intervention(s): Complete history and physical examinations, including endovaginal ultrasounds, dermatologic assessments, completion of Beck Depression Inventory Fast Screen (BDI-FS), and serum testing. Main Outcome Measure(s): Scores >4 on BDI-FS indicated a positive screen for depression. Scores were further subdivided into mild (5–8), moderate (9–12), and severe (>12) depression risk. Insulin resistance was assessed using the Homeostasis Model Assessment of Insulin Resistance (HOMA-IR). Result(s): A total of 131 women (44%) were at risk for depression, determined by positive BDI-FS screening. These patients had higher BMI (32.3 vs. 28.5), and elevated insulin resistance, assessed by HOMA-IR (5.2 vs. 2.6), compared with patients with negative depression screening. In a stratified analysis by BMI category, obese women with positive depression screens had elevated HOMA-IR, compared with obese women with normal BDI-FS scores (7.4 vs. 4.1). In a multivariate logistic regression analysis, HOMA-IR was independently related to the odds of depression risk after controlling for age, ethnicity, BMI, and exercise (odds ratio: 1.07). Conclusion(s): Depression is common in PCOS. After controlling for confounders in multivariate regression analyses, we found HOMA-IR to be significantly associated with depression risk. Our data suggest a complex interplay among insulin resistance, obesity, and depression in PCOS, warranting additional investigation. Mental health assessment is indicated in comprehensive care of patients with PCOS.

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