Increased Progesterone Receptor Expression in Uterine Leiomyoma: Correlation with Age, Number of Leiomyomas, and Clinical Symptoms  

Oleh:

Tsigkou, Anastasia ; Reis, Fernando M. ; Meng H. Lee ; Bingjie Jiang ; Tosti, Claudia ; Centini, Gabriele ; Fang-Rong Shen ; You-Guo Chen ; Petraglia, Felice

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Fertility and Sterility (keterangan: ada di ClinicalKey) vol. 104 no. 01 (Jul. 2015), page 170–175.
Topik: Abnormal Uterine Bleeding; Dysmenorrhea; Myometrium; Progesterone Receptors; Uterine Leiomyoma
Fulltext: F02 v104 n1 p170 kelik2016.pdf (534.65KB)

Ketersediaan

Perpustakaan FK Nomor Panggil: F02.K Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Objective: To investigate the possible correlation between progesterone receptor (PR) expression in uterine leiomyoma or adjacent myometrium and patient's age, size/number of leiomyomas, or clinical symptoms such as dysmenorrhea, acyclic pelvic pain, or menstrual and intermenstrual uterine bleeding. Design: Cross-sectional study. Setting: Referral center. Patient(s): Sixty-two Chinese women undergoing elective hysterectomy for uterine leiomyomata. Intervention(s): None. Main Outcome Measure(s): Evaluation of PR-total and PR-B mRNA with real-time polymerase chain reaction; PR-A and PR-B proteins quantified by Western blot in leiomyoma tissue and myometrium; symptoms rated by the patients using visual analog scores. Result(s): The PR-B mRNA and PR-A and PR-B proteins were more concentrated in leiomyomas than in matched myometrium. A direct correlation between PR-B mRNA levels in leiomyoma and age (r = 0.347) and number of tumors (r = 0.295) was found. Conversely, there was an inverse correlation between PR-B mRNA levels in leiomyoma and dysmenorrhea (r = -0.260) and intermenstrual bleeding (r = -0.266). Multiple regression analysis indicated that age (ß = 0.363) and the number of myomas (ß = 0.296) were independently associated with PR-B mRNA levels in leiomyoma tissue. Conclusion(s): The levels of PR-B mRNA in leiomyoma tissue are directly associated with the number of tumors and inversely correlated with the intensity of intermenstrual bleeding and dysmenorrhea, suggesting that PR signaling may favor leiomyoma growth while attenuating clinical symptoms. This duality should be taken into account in the clinical management of patients with symptomatic uterine leiomyoma.

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