Preconception Blood Pressure and Risk of Preterm Birth: A Large Historical Cohort Study in a Chinese Rural Population  

Oleh:

Ying Yang ; Yuan He ; Qian Li ; Yuanyuan Wang ; Zuoqi Peng ; Jihong Xu ; Xu Ma

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Fertility and Sterility (keterangan: ada di ClinicalKey) vol. 104 no. 01 (Jul. 2015), page 124–130.
Topik: Preterm Birth; Blood Pressure; Pre-Pregnancy; Cohort Study
Fulltext: F02 v104 n1 p124 kelik2016.pdf (413.08KB)

Ketersediaan

Perpustakaan FK Nomor Panggil: F02.K Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Objective: To examine the relationship between preconception blood pressure (BP) and the risk of preterm birth (PTB) using a historical cohort of reproductive-aged women and girls from a Chinese rural population. Design: A historical cohort study established between 2010 and 2013 in People's Republic of China. Setting: Local family-planning service agencies and maternal–child care service centers. Patient(s): A total of 367,425 reproductive-aged women and girls who participated in the National Free Pre-pregnancy Checkups in 2010–2012 and subsequently had a live birth before October 2013. Intervention(s): None. Main Outcome Measure(s): Incidence rates of PTB in reproductive-aged women and girls across preconception BP levels. Result(s): Preterm births were defined as babies born alive at 28 to 37 weeks of pregnancy. Compared with the participants with a systolic BP of <120 mm Hg, the multivariable-adjusted odds ratio (OR) for PTB was 0.99 (95% confidence interval [CI]: 0.95–1.03]), 1.21 (95% CI: 1.11–1.32), 1.47 (95% CI: 1.22–1.77), 1.80 (95% CI: 1.25–2.59), and 1.81 (95% CI: 1.20–2.73) for the participants with systolic BP of 120–129, 130–139, 140–149, 150–159, and =160 mm Hg, respectively. When the participants with normal BP were used as the reference, the adjusted OR for PTB was 1.04 (95% CI: 1.01–1.08), 1.38 (95% CI: 1.25–1.53), and 1.54 (95% CI: 1.21–1.97) for the participants with prehypertension, stage-1 hypertension, and stage-2 hypertension, respectively. In addition, isolated systolic and diastolic hypertension increased the risk of PTB by 55% and 30%, respectively. Conclusion(s): Our results indicated a strong linear and independent relationship between BP levels and the risk of PTB in Chinese reproductive-aged women and girls. Maternal hypertension before pregnancy can significantly increase the risk of PTB.

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