EBV-Positive Mucocutaneous Ulcer of the Oral Cavity Associated with HIV/AIDS  

Oleh:

Bunn, Belinda ; Willie van Heerden

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology (keterangan: ada di ClinicalKey) vol. 120 no. 06 (Dec. 2015), page 725–732.
Topik: Oral; Maxillofacial Pathology

Ketersediaan

Perpustakaan FK Nomor Panggil: O04.K Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

Objective: To present 2 cases of Epstein-Barr virus (EBV)–positive mucocutaneous ulcer of the oral mucosa in association with human immunodeficiency virus infection. Study design:;Two recently diagnosed cases of EBV-positive mucocutaneous ulcer of the oral mucosa in patients with human immunodeficiency virus (HIV) were reviewed with regard to their clinical, histomorphologic, and immunophenotypic features. Results: Both cases presented clinically as well-circumscribed ulcers that were histomorphologically characterized by dense superficial polymorphous inflammatory infiltrates. The infiltrates comprised cells with a predominant B-cell phenotype that ranged in size from small to intermediate with occasional large immunoblastic forms. Some of the larger B cells had a Reed-Sternberg–like morphology. The B cells were positive for CD20 and coexpressed CD30 and to a lesser extent CD15. Epstein–Barr virus-encoded small RNA (EBER) positivity was detected in most of the B cells. Conclusions: EBV-positive mucocutaneous ulcer represents an unusual form of lymphoproliferative disorder associated with immune suppression. It should be distinguished from other forms of HIV-associated oral ulceration.

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