Relationship between Cutaneous Polyarteritis Nodosa (cPAN) and Macular Lymphocytic Arteritis (MLA): Blinded Histologic Assessment of 35 cPAN Cases  

Oleh:

Battistella, Maxime ; Vignon-Pennamen, Marie-Dominique ; Buffiere-Morgado, Amandine ; Rybojad, Michel ; Petit, Antoine ; Cordoliani, Florence ; Begon, Edouard ; Flageul, Beatrice ; Mahr, Alfred ; Bagot, Martine ; Bouaziz, Jean-David

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: JAAD: Journal of the American Academy of Dermatology (keterangan: ada di ClinicalKey) vol. 73 no. 06 (Dec. 2015), page 1013-1020.
Topik: Cutaneous Periarteritis Nodosa; Lymphocytic Thrombophilic Arteritis; Macular Arteritis; Macular Lymphocytic Arteritis; Periarteritis Nodosa; Vasculitis

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Perpustakaan FK Nomor Panggil: J15.K Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Background: Cutaneous polyarteritis nodosa (cPAN) is a skin medium vessel neutrophilic arteritis with livedo, nodules, and ulcerations. Macular lymphocytic arteritis (MLA) is a small arteritis with erythematous or pigmented macules and typical histologic features (a lymphocytic infiltrate, concentric fibrin ring, no disruption of the internal elastic lamina). Objective: We sought to assess the frequency of clinical and histologic features of MLA in patients with cPAN. Methods: This was a monocentric retrospective analysis of patients given the diagnosis of cPAN with blinded assessment of skin biopsy specimens. Results: All 35 patients included had an infiltrated livedo, nodules, or both. Ulceration was rare. Erythematous or pigmented lesions were present in 54% of patients. Predominantly lymphocytic arteritis, a paucity of neutrophils, concentric fibrin ring, and absence of internal lamina elastic disruption were present in 60%, 20%, 18%, and 23% of patients, respectively. Median follow-up was 11 years. None of the patients had systemic involvement, and 57% had a complete remission. The incidence of complete remission was not different between patients having a predominant lymphocyte infiltrate or few neutrophils. Limitations: This was a retrospective, monocentric study without a control group of patients with MLA. Conclusions: Our data do not favor the classification of cPAN and MLA as distinct entities.

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