Clinical and Dermoscopic Features of Combined Cutaneous Squamous Cell Carcinoma (SCC)/Neuroendocrine [Merkel Cell] Carcinoma (MCC)  

Oleh:

Suarez, Andrea Luisa ; Louis, Peter ; Kitts, Jasmine ; Busam, Klaus ; Myskowski, Patricia L. ; Wong, Richard J. ; Chih-Shan Jason Chen ; Spencer, Philip ; Lacouture, Mario ; Pulitzer, Melissa P.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: JAAD: Journal of the American Academy of Dermatology (keterangan: ada di ClinicalKey) vol. 73 no. 06 (Dec. 2015), page 968-975.
Topik: Biphenotypic; Dermoscopy; Merkel Cell; Neuroendocrine Carcinoma; Polyomavirus; Ultraviolet Signature

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Perpustakaan FK Nomor Panggil: J15.K Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Background: Merkel cell carcinoma (MCC) is a neuroendocrine carcinoma, associated with Merkel cell polyomavirus. MCC admixed with squamous cell carcinoma (SCC) is unassociated with polyomavirus, and is genetically distinct. Objective: We sought to distinguish clinically and dermoscopically between MCC and SCC/MCC. Methods: We compared patient data for SCC/MCC (n = 26) and MCC (n = 20), and reviewed clinical and dermoscopic images (n = 9) of SCC/MCC. Results: Patients with SCC/MCC were older (median 76.5 vs 69 years) and more often male (77% vs 60%), and had more nonmelanoma skin cancer (85% vs 25%), malignant extracutaneous tumors (25% vs 5%), lymphoproliferative disorders (23% vs 10%), and immunodeficient/proinflammatory states (77% vs 35%). In all, 58% of SCC/MCC versus 10% of MCC were clinically diagnosed nonmelanoma skin cancer. Patients with SCC/MCC had more metastases (77% vs 40%), more treatment failures (53% vs 45%), shorter survival (41 vs 54 months), and more death from disease (50% vs 40%). SCC/MCC demonstrated marked scale (7/9), and telangiectasia (1/9). Dermoscopically, small dotted and short linear irregular peripheral vessels and central milky-red areas with large-diameter arborizing vessels were seen. Limitations: The rarity of SCC/MCC limits available data. Conclusions: SCC/MCC is aggressive, arising within elderly patients' chronically ultraviolet-exposed skin, often in the setting of immunosuppression or inflammation. Dermoscopically, polymorphous vessels in lesions suspicious for nonmelanoma skin cancer are suggestive.

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