Identification and Bioactivity Studies of Flavonoid Compounds from Macaranga hispida (Blume) Mull.Arg  

Oleh:

Megawati ; Saepudin, Endang ; Hanafi, Muhammad ; Darmawan, Akhmad ; Lotulung, Puspa Dewi N.

Jenis: Article from Journal - ilmiah nasional - terakreditasi DIKTI
Dalam koleksi: Makara Seri Sains vol. 19 no. 3 (Sep. 2015), page 96-100.
Topik: anti cancer murine leukemia P-388 cell lines; antioxidant activity; BSLT; kaempferol 7-O-glucose; cytotoxicity; Macaranga hispida (Blume) Mull. Arg; 5; 7; 3’; 4’-tetrahydroxy-6-geranyl flavonol
Fulltext: 4848-9088_her.pdf (97.95KB)

Isi artikel

Two flavonoid compounds, 5,7,3’,4’-tetrahydroxy-6-geranylflavonol (1) and kaempferol 7-O-ß-glucose (2) have been isolated from the leaves of Macaranga hispida (Blume), Mull.Arg. Isolation and purification were conducted by chromatography methods and chemical structure characterization was carried out by spectroscopic methods. The 5,7,3’,4’-tetrahydrxyi-6-geranyl flavonol (1) and kaempferol 7-O-glucose (2) had moderate cytotoxic activity against murine leukemia P-388 cell lines with IC 50 value of 0.22 and 101.5 µg/mL, respectively. The IC for antioxidant activities of (1) and (2) were 2.83 and 13.95 µg/mL, respectively. The LC of (1) and (2) from BSLT were 350 and >1000 µg/mL, respectively.

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