Artemisinin-napthoquine versus dihydroartemisinin-piperaquine in adult subjects with Plasmodium vivax infection  

Oleh:

Tjitra, Emiliana ; Hasugian, Armedy Ronny ; Siswantoro, Hadjar ; Fay, Michael P

Jenis: Article from Journal - ilmiah nasional
Dalam koleksi: Health Science Journal of Indonesia vol. 06 no. 02 (Dec. 2015), page 92-98.
Topik: malaria; artemisinin; napthoquine; dihydroartemisinin; vivax

Ketersediaan

Perpustakaan PKPM Nomor Panggil: H25 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada	Lihat Detail Induk
Perpustakaan FK Nomor Panggil: H25.K Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada	Lihat Detail Induk

Isi artikel

Background: This study was to compare the efficacy and safety between Artemisinin-Napthoquine (AN) as a single dose as well as an alternative drug, and Dihydroartemisinin-Piperaquine (DHP) as a three-day standard regimen on P. Vivax infection. Method: This was an open randomized study performed during the period of April 2007-March 2008 in three Armed Forces Hospitals in Jayapura, Papua Provice, and one private hospital in Maumere, East Nusa Tenggara Province. This study was a part from previously published study for any malaria infection. Efficacy was the absence of clinical and parasitological malaria until day 42, performed based on adverse event in any day of follow up which never reported at day recruitment. Results: This study analyses 158 P. Vivax cases. A total 80 subjects were treated with AN and 78 with DHP. The median Parasite Clearance Estimator (PCE) was 2.32 (range:1.42-7.78; Interquartile Range (IQR); 1.99-2.82) hours in AN and 2.05 (range:1.30-8.30; IQR:1.82-2.46) hours in DHP group. The parasite clearance was complate by 64 hours. The ACPR was 100% (95% Confidance Interval (CI): 95.2-100) in the AN, and 100% (95% CI : 94.9-100) in the DHP group. Both drugs have similiar mild and tolerated adverse events. Conclusion: Both drugshave similiar efficacy and safety for the treatment of P. Vivax in adults. Although AN has took longer PCE compared to DHP, 100% clearence was achieved in both groups in 64 hours.

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