Squaric acid sensitization is not required for response in the treatment of alopecia areata  

Oleh:

Vedak, Priyanka ; Kroshinsky, Daniela

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: JAAD: Journal of the American Academy of Dermatology (keterangan: ada di ClinicalKey) vol. 73 no. 03 (Sep. 2015), page 471–476.
Topik: alopecia areata; squaric acid dibutylester; topical immunotherapy

Ketersediaan

Perpustakaan FK Nomor Panggil: J15.K Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Background Topical immunotherapy using potent contact allergens, such as squaric acid dibutylester (SADBE), can be used to treat alopecia areata. However, there are conflicting reports regarding the best protocol for its administration, particularly with regard to the necessity of an eczematous response after the initial sensitization treatment. Objectives We sought to assess the impact of initial sensitization on subsequent hair regrowth. Methods This is a retrospective review of the use of SADBE in the treatment of alopecia areata in 14 patients. Results Eleven of 14 patients underwent initial sensitization before initiating treatment. Three of these patients had an eczematous reaction after 1 attempt, 5 after =2 attempts, and 3 failed to develop a clinical reaction. Four of 14 initiated treatment without a clinical reaction or a previous sensitization. Eleven of 14 patients experienced regrowth, 7 with previous sensitization and 4 without. Limitations This observational study is limited by sample size. Conclusions SADBE sensitization regimens and reactions vary widely, and the absence of an initial eczematous reaction to sensitization does not predict a failed response with continued SADBE treatment.

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