Inferior outcomes in immunosuppressed patients with high-risk cutaneous squamous cell carcinoma of the head and neck treated with surgery and radiation therapy  

Oleh:

Manyam, Bindu V. ; Gastman, Brian ; Zhang, Alexandra Y. ; Reddy, Chandana A. ; Burkey, Brian B.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: JAAD: Journal of the American Academy of Dermatology (keterangan: ada di ClinicalKey) vol. 73 no. 02 (Aug. 2015), page 221–227 .
Topik: cutaneous squamous cell carcinoma; head and neck; high-risk skin cancer; immunosuppressed; radiation; transplantation

Ketersediaan

Perpustakaan FK Nomor Panggil: J15.K Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Background Immunosuppressed patients have higher rates of cutaneous squamous cell carcinoma of the head and neck. Objective This study reviews the effect of immune status on disease characteristics and treatment outcomes. Methods Patients with cutaneous squamous cell carcinoma of the head and neck treated with surgery and postoperative radiotherapy between 2000 and 2011 were included. Immunosuppressed patients underwent prior organ transplantation or chemotherapy. Baseline variables were compared using ?2 and unpaired t tests. Overall survival and disease-free survival were calculated using the Kaplan-Meier method. Results In this study of 59 patients, 38 (64%) were immunocompetent and 21 (36%) were immunosuppressed. Most patients had recurrent tumors (63%) and node-positive disease (61%), which were well balanced between the groups. Poorly differentiated tumors (62% vs 21%; P = .009), lymphovascular invasion (29% vs 11%; P = .08), and extracapsular extension (57% vs 41%; P = .09) were more frequent in the immunosuppressed group. Two-year disease-free survival (45% vs 62%) and 2-year overall survival (36% vs 67%) were inferior for immunosuppressed patients. Limitations Limitations include single institution, retrospective study with small sample size, and potential referral bias. Conclusions Immunosuppressed patients with cutaneous squamous cell carcinoma of the head and neck more frequently present with high-risk pathologic features and inferior outcomes. Early multidisciplinary assessment and alternate management strategies merit prospective investigation.

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