Atypical clinicopathologic presentation of primary cutaneous diffuse large B-cell lymphoma, leg type  

Oleh:

Massone, Cesare ; Fink-Puches, Regina ; Wolf, Ingrid ; Zalaudek, Iris ; Cerroni, Lorenzo

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: JAAD: Journal of the American Academy of Dermatology (keterangan: ada di ClinicalKey) vol. 72 no. 06 (Jun. 2015), page 1016–1020 .
Topik: annular erythema; clinical presentation; cutaneous B-cell lymphoma; primary cutaneous diffuse large B-cell lymphoma; leg type

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Perpustakaan FK Nomor Panggil: J15.K Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Background Primary cutaneous diffuse large B-cell lymphoma, leg type (cDLBCL-LT) is a well-defined entity of cutaneous B-cell lymphoma affecting predominantly elderly patients, mostly women. The typical clinical presentation is characterized by solitary or multiple, rapidly growing plaques or tumors on 1 leg (rarely both legs). Objective We sought to describe a new clinical variant of cDLBCL-LT that deviates from the conventional one. Methods Clinical, histopathologic, phenotypical, and molecular features of 3 cases of cDLBCL-LT presenting with patches or thin plaques were reviewed (all were women, aged 60, 62, and 87 years; lesions were located on the leg in all patients). Results These patients presented with patches or thin plaques that represented the first manifestation of cDLBCL-LT. All 3 patients reported a history of long-standing lesions (present for 6, 9, and 18 months, respectively). Histology revealed moderately dense, perivascular infiltrates of small lymphocytes admixed with variable numbers of large cells that were CD20+, Bcl-2+, and MUM-1+. Limitations There were only a small number of cases. Conclusions We reported an unusual clinical presentation of cDLBCL-LT that deviates from the conventional one and that represents a formidable diagnostic challenge. Biopsy specimens of unusual patches/thin plaques or annular lesions should be obtained from the legs of adult patients if the lesions do not respond to conventional treatment.

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