Modulation of Brain-Derived Neurotrophic Factor (BDNF)-Induced Trophic Signalling as an Alternative Treatment for Alzheimer’s Disease  

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Muthmainah

Jenis: Article from Journal - ilmiah nasional - tidak terakreditasi DIKTI
Dalam koleksi: Cermin Dunia Kedokteran vol. 42 no. 07 (Jul. 2015), page 534-536.
Topik: Alzheimer’s Disease; Alternative Treatment; BDNF; Trophic Signalling

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Perpustakaan FK Nomor Panggil: C04.K Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Alzheimer’s disease (AD) is a disorder of synaptic function and neuronal degeneration characterized by decline in memory and cognition as well as changes of personality. Brain-Derived eurotrophic Factor (BDNF) is a major modulator of synaptic plasticity and is an acknowledged pharmacological target for the treatment of a range of neurological disorders including AD. Attempts to supply BDN Fexogenously are limited by side effects. An alternative strategy to enhance BDNF-induced trophic signalling is through amplifi cation of neural response to the reduced supply of endogenous BDNF found in AD.

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