Pharmacogenomics and Personalized Medicine in Type 2 Diabetes  

Oleh:

Yudhani, Ratih Dewi

Jenis: Article from Journal - ilmiah nasional - tidak terakreditasi DIKTI
Dalam koleksi: Cermin Dunia Kedokteran vol. 42 no. 06 (Jun. 2015), page 419-424.
Topik: Type 2 Diabetes Mellitus; Pharmacogenetics; Oral Diabetics Drugs; Personalized Medicine
Fulltext: C04 v42 n6 p419 kelik2017.pdf (170.87KB)

Ketersediaan

Perpustakaan FK Nomor Panggil: C04.K Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Type 2 diabetes mellitus (T2DM) has reached epidemic proportions worldwide and poses a considerable concern for public health. Although a variety of pharmacological treatments is available, but response, doses, and tolerability to drugs are highly variable and monotherapyoften failed. A large interindividual variability in drug response has been noticed and contributing factors include age, sex, disease, drug and food interactions, comorbidity, as well as genetic factors. Large variability related to hypoglycemic drug therapy response is often encountered in the clinic. Poor therapeutic outcomes may be caused by variability of individual characteristics. Personalized medicine is an emerging concept for treating diseases, which involves determining specific information of a particular patient and then prescribing specific treatment. Pharmacogenetics holds the promise of bringing personalized medicine to drug dosing decisions, to reduce morbidity and mortality, and to improve life quality for T2DM patients.

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