Micro-ribonucleic acid 143 (MiR-143) inhibits oral squamous cell carcinoma (OSCC) cell migration and invasion by downregulation of phospho-c-Met through targeting CD44 v3  

Oleh:

Ping Xu ; Yan, Li ; Shuyong, Yang ; Haiyuan, Yang ; Juan, Tang ; Mingzhe, Li

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology (keterangan: ada di ClinicalKey) vol. 120 no. 01 (Jul. 2015), page 43–51 .

Ketersediaan

Perpustakaan FK Nomor Panggil: O04.K Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

Objective The aim of this study was to investigate the roles and mechanisms of Micro-ribonucleic acid 143 (miR-143) in oral squamous cell carcinoma cells. Study Design Following the detection of miR-143 expression, cell proliferation, migration, and invasion assays and Western blot analysis were conducted in the oral squamous cell carcinoma (OSCC) cell lines. Results We found that the expression of miR-143 was significantly decreased in the OSCC cell lines (SCC-4, Tca-8113, CAL-27) and tumor tissues. Meanwhile, miR-143 was significantly correlated with the migration and invasion in OSCC cell lines. Further investigation revealed that the expression level of miR-143 was opposite to that of its potential target gene—CD44 v3 and was also related to phospho-c-Met activation. Conclusions miR-143 could exert significantly suppressive effects on the ability of migration and invasion in OSCC cell lines, and the mechanism of this might be related to the activity of phospho-c-met though the CD44 v3/HGF signal. miR-143 could thus provide new applications for the treatment of OSCC.

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