Sex, Adiposity, and Hypertension Status Modify the Inverse Effect of Marine Food Intake on Blood Pressure in Alaska Native (Yup’ik) People  

Oleh:

Beaulieu-Jones, Brendin R ; Brien, Diane M O ; Hopkins, Scarlett E. ; Moore, Jason H ; Boyer, Bert B. ; Gilbert-Diamond, Diane

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: JN: The Journal of Nutrition vol. 145 no. 05 (May 2015), page 931-938 .
Topik: biomarker; effect modification; ypertension; indigenous people; marine food intake

Ketersediaan

Perpustakaan FK Nomor Panggil: J42.K Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Background: Alaska Native people currently have a higher prevalence of hypertension than do nonnative Alaskans, although in the 1950s hypertension was rare among Alaska Native people. A novel biomarker of marine foods, the nitrogen isotope ratio (d15N) in RBCs was shown to be negatively associated with systolic and diastolic blood pressure. Few studies have examined how individual characteristics modify the association of marine food intake with blood pressure. Objective: This exploratory analysis examined whether sex, adiposity, and hypertension modify the inverse association between marine food intake and blood pressure. Methods: We used covariate-adjusted linear models to describe the association between d15N and blood pressure in 873 adult Alaska Native (Yup’ik) people who resided in 8 communities in southwest Alaska. We separately stratified by sex, body mass index (BMI) group, abdominal obesity, and hypertension status and assessed the interaction between d15N and participant characteristics on blood pressure via likelihood ratio tests. Results: The association between d15N and systolic blood pressure was modified by sex, BMI status, and abdominal obesity, with the inverse association observed only in the male (ß = -1.5; 95% CI: -2.4, -0.6), nonobese BMI (ß = -1.7; 95% CI: -2.5, -1.0), and non–abdominally obese (ß = -1.6; 95% CI: -2.4, -0.9) strata (all P-interaction < 0.0001). A reduction in diastolic blood pressure associated with d15N was observed in the nonobese BMI (ß = -1.1; 95% CI: -1.7, -0.5) and non–abdominally obese (ß = -1.1; 95% CI: -1.7, -0.5) strata, although only the interaction between BMI group and d15N with diastolic blood pressure was significant. The inverse association between d15N and both systolic and diastolic blood pressure was observed in nonhypertensive individuals, although the comparison had limited power. The results were consistent with those identified by using combined RBC concentrations of eicosapentaenoic acid and docosahexaenoic acid as the biomarker of marine food intake, although the associations identified by using d15N were larger. Conclusions: Obesity status modified the inverse association between marine food intake and both systolic and diastolic blood pressure in adult Alaska Native (Yup’ik) people. The inverse association between d15N and systolic blood pressure was also modified by sex.

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