Circadian Rest–Activity Rhythms Predict Future Increases in Depressive Symptoms Among Community-Dwelling Older Men  

Oleh:

Smagula, Stephen F. ; Ancoli-Israel, Sonia ; Blackwell, Terri ; Boudreau, Robert ; Stefanick, Marcia L.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: The American Journal of Geriatric Psychiatry (keterangan: ada di ClinicalKey) vol. 23 no. 05 (May 2015), page 495–505 .
Topik: Aging; circadian rest-activity rhythm (CAR); depression; epidemiology

Ketersediaan

Perpustakaan FK Nomor Panggil: A35.K Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

Objective Circadian rest-activity rhythms (CARs) have been cross-sectionally associated with depressive symptoms, although no longitudinal research has examined whether CARs are a risk factor for developing depressive symptoms. Methods We examined associations of CARs (measured with actigraphy over a mean of 4.8 days) with depressive symptoms (measured with the Geriatric Depression Scale) among 2,892 community-dwelling older men (mean age: 76.2 ± 5.5 years) from the MrOS Sleep Study who were without cognitive impairment. Among 2,124 men with minimal (0–2) symptoms at baseline, we assessed associations between CAR parameters and increases to mild (3–5) or clinically significant (=6) symptoms after an average of 1.2 (±0.32) years. Results Cross-sectional associations between rhythm height parameters were independent of chronic diseases, lifestyle, sleep, and self-reported physical activity covariates. For example, men in the lowest mesor quartile had twice the adjusted odds (adjusted odds ratio [AOR]: 2.04, 95% confidence interval [CI]: 1.36–3.04, p = 0.0005) of having prevalent clinically significant symptoms (compared to minimal). Longitudinally, low CAR robustness (being in the lowest quartile of the pseudo-F statistic) was independently associated with increasing odds of developing symptoms (i.e., AOR for having clinically significant depressive symptoms at follow-up = 2.58, 95% CI: 1.11–5.99, p = 0.03). Conclusion CAR disturbances are indicative of depressive symptomology. Low CAR robustness may independently contribute to the risk of worsening depression symptomology.

Opini Anda

Klik untuk menuliskan opini Anda tentang koleksi ini!

Kembali