Surgical treatment of solid pseudopapillary neoplasms of the pancreas and risk factors for malignancy  

Oleh:

Kim, M.J. ; Choi, D.W. ; Choi, S.H. ; Heo, J.S.

Jenis: Article from Article - diterbitkan di jurnal ilmiah internasional
Dalam koleksi: BJS: British Journal of Surgery vol. 101 no. 10 (Sep. 2014), page 1266-1271.
Topik: pancreatic disorder; young women; surgical resection; neoplasm; kanker; antigen; pancreatectomy; laparoscopic

Ketersediaan

Perpustakaan FK Nomor Panggil: B15.K Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Background The aim of this study was to identify clinical predictors of malignancy and surgical strategies for pancreatic solid pseudopapillary neoplasm (SPN) by analysis of surgical outcomes at a single institution. Methods All patients who underwent surgery for SPN between 1995 and 2010 were identified. Histopathology slides of all patients were reviewed by a specialized pathologist and the neoplasms were classified according to the criteria of the World Health Organization 2010. Results Of the 106 patients identified, 85 (80·2 per cent) were female, and the median age was 36 (range 10–65) years. Median tumour size was 4·5 (range 1·0–15·0) cm. Some 17 patients (16·0 per cent) were classified as having a high-grade malignant SPN. Tumour size of at least 5?cm was associated with high-grade malignant potential (P?=?0·022). Although lymph nodes were removed from 40 patients (37·7 per cent), there were no nodal metastases. A total of five patients underwent en bloc resection of adjacent structures, including two with portal vein involvement. After a median follow-up of 56·9?months, two patients with high-grade malignant SPN had evidence of tumour recurrence in the lymph nodes and liver. Conclusion SPN with a diameter of 5?cm or more is associated with a high-grade malignant phenotype. Complete surgical removal is associated with low recurrence rates.

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